It has been an hour now since I witnessed Coralie Fargeat’s “The Substance,” and I am absolutely convinced I will not see a more bug fuck crazy motion picture in 2024. It combines the extreme body horror of David Cronenberg’s films (“The Fly” in particular), the graphic effects of John Carpenter’s “The Thing,” and the brutal satire of “Network” to create a truly unforgettable motion picture which serves as a middle finger to unrealistic beauty standards, and also a reflection of our own internal biases which we don’t always face up to.

Demi Moore, in what may very well be her finest performance ever, stars as Elisabeth Sparkle, an Oscar winning actress who is currently hosting an aerobics show on television. It is also her birthday, her 50^th to be exact, and while everyone is quick to wish her well, her boss Harvey (Dennis Quaid) is out to fire her as he sees her as being too old in a business which is constantly looking for young blood on an endless basis. In the process, what should be the happiest day of the year for her is now the worst ever as she is instantly rendered irrelevant in the eyes of many, and she barely survives a truly horrific car crash which would have killed anyone else.

Salvation, however, just might be coming her way when she is encouraged by a doctor to try a black-market serum which is simply called The Substance. It looks a lot like the one Herbert West used to awaken dead corpses in “Re-Animator,” and a sexy male voice, which sounds like it is about to say “I really am as sexy as I sound” tells her this serum will create a “younger, more beautiful, more perfect” counterpart of herself. This counterpart ends up emerging from a huge slit in her back in a style reminiscent of “Videodrome,” and while the situation might seem normal, we know this will eventually descend into an inferno no one could ever see coming.

The counterpart is Sue, and she is played ever so unforgettably by Margaret Qualley. Sue ends up auditioning for the job Elisabeth was fired from, gets hired for it, and she becomes a huge sensation in what seems like no time at all. Fargeat really takes the time to show off Sue’s alluring body and curves as she conducts her workout television show as if she is giving pointers on how to have great sex with your lover.

“The Substance” does take its time building up its characters and the serum both become a slave to, but it is all worth it as gives audiences much to enjoy before Fargeat rips the rug out from right underneath us and sends us all in a downward spiral Nine Inch Nails would have loved to make an album out of.

One term which stands out in this film is “respect the balance,” but it eventually becomes clear that Sue cannot as the demands on her become increasingly strenuous to where she uses more of the “stabilizer fluid” from Elisabeth than she has any right to. As a result, Elisabeth starts to see some startling deformations on her body which alarms her to a terrifying extent.

This is where the body horror of “The Substance” comes into full focus as Elisabeth realizes she needs to stop taking the serum, but losing Sue’s infinite success in a business which has pushed her coldly to the side becomes too terrifying to endure. As the story continues, it all becomes incredibly grotesque to where we as an audience become inescapably horrified than she is at the horrors none of us could ever be prepared for. How bad does it get? Well, let me put it this way; there is a track on Raffertie’s wonderfully propulsive soundtrack entitled “Golem.” Need I say more? Well, it’s safe to say this serum will not exactly be “my precious.”

There were a number of other movies I was reminded of while watching “The Substance.” The first was “Requiem for a Dream” in which we watch addicts struggle to obtain the American Dream by any means necessary only to find a pathway to a hell of their own making. Watching Sue continually drain stabilizer fluid out of Elisabeth reminded me of Jared Leto’s abscessed vein in “Requiem for a Dream” in which he injected heroin into. The abscessed veins in both movies are truly horrifying sights to see, and do not promise a better future for either character.

I am also reminded of David Cronenberg’s remake of “The Fly” while watching this film as body parts falling off the human body here have not been as mortifying as watching Jeff Goldblum’s ear fall off in front of Geena Davis. Sitting in a large audience while watching “The Substance,” there was no denying the strong reactions to t characters lose various body parts as it all kept leading to a horrific conclusion much like the one in Brian De Palma’s adaptation of “Carrie.”

Is this really Demi Moore’s finest hour? It may very well be, but this might imply that all her work before this doesn’t measure up, and that’s just insulting. I think she deserved more credit than she got for her work in “A Few Good Men,” and her performance in “G.I. Jane” is one I will never ever forget. In “The Substance,” she is perfectly cast as an actress whom many will be foolishly quick to say is past her prime as it says more about them than it ever will about her. She fully invests herself into the character of Elisabeth Sparkle, and she looks as fabulous as she ever has in the process.

But moreover, Moore has an unforgettable scene in which we see her preparing to go out on a date with an old school friend, only to hate what she sees in the mirror. Watching her violently wipe the makeup off her face reveals a self-hatred we have all experienced at one point in our crazy lives, and the effect this has on her is quite profound thanks to Moore.

Margaret Qualley makes Sue into more than a sex symbol of her time. Instead, she makes her into a person who is instantly gifted a stardom many others spend their lives striving for while the odds remain as astronomical as ever. Seeing her handle this newfound fame is something she makes all the more palpable throughout even as Sue descends into a hell of her own making which results in one of the bloodiest climaxes ever seen in a motion picture.

Just when you think “The Substance” cannot get crazier or bloodier than it already has, you are thrillingly proved wrong in epic fashion. But while I thought this film would descend into the same cinematic chaos which would leave forever psychologically scarred as “Requiem for a Dream” did, Fargeat gives the proceedings a good deal of satirical humor which helps to soften the blow. In fact, it makes everything all the more insidiously fun as we come to see this story will have an inevitably dark ending.

While we are at, I do have to single out Dennis Quaid’s unabashedly shameless performance as Harvey, the producer who heartlessly casts Elisabeth aside and hires Sue because she is ever so young. Quaid is truly sublime and hateful as he takes this heartless character and makes even more heartless than he already is. Seeing him gorge on an endless number of shrimps at the movie’s start is enough to make you see how selfish and thoughtless this guy is, and it is presented us in truly disgusting detail. Basically, he is as slimy as the shrimp he eats, but you all can see this even before he eats the last one on his plate.

“The Substance” is not a cinematic experience I will ever forget, and it is one of the best movies of 2024. In the process of giving us such an insane film, Fargeat gives a huge middle finger to those who continue to hold beauty standards to an obscene and unrealistic standard even this period of the Me Too and Time’s Up movements. It offered up an insanely good time, and watching it with a large audience made it all the more thrilling. If there is any movie out right now which invites you to see and experience it on the big screen, it’s this one.

* * * * out of * * * *